Machines on Genes: Enzymes that Make, Break and Move DNA and RNA

As the vital information repositories of the cell, the nucleic acids DNA and RNA pose many challenges as enzyme substrates. To produce, maintain and repair DNA and RNA, and to extract the genetic information that they encode, a battery of remarkable enzymes has evolved, which includes translocases, polymerases/replicases, helicases, nucleases, topoisomerases, transposases, recombinases, repair enzymes and ribosomes. An understanding of how these enzymes function is essential if we are to have a clear view of the molecular biology of the cell and aspire to manipulate genomes and gene expression to our advantage. To bring together scientists working in this fast-developing field, the Biochemical Society held a Focused Meeting, ‘Machines on Genes: Enzymes that Make, Break and Move DNA and RNA’, at Robinson College, University of Cambridge, U.K., in August 2009. The present article summarizes the research presented at this meeting and the reviews associated with the talks which are published in this issue of Biochemical Society Transactions

Discovery of a Spin-Down State Change in the LMC Pulsar B0540-69

We report the discovery of a large, sudden, and persistent increase in the spin-down rate of B0540-69, a young pulsar in the Large Magellanic Cloud, using observations from the Swift and RXTE satellites. The relative increase in the spin-down rate of 36% is unprecedented for B0540-69. No accompanying change in the spin rate is seen, and no change is seen in the pulsed X-ray emission from B0540-69 following the change in the spin-down rate. Such large relative changes in the spin-down rate are seen in the recently discovered class of 'intermittent pulsars', and we compare the properties of B0540-69 to such pulsars. We consider possible changes in the magnetosphere of the pulsar that could cause such a large change in the spin-down rate.Comment: 6 pages, 2 figures, accepted for publication in ApJ Letter

Imaging X-ray spectrometer

An X-ray spectrometer for providing imaging and energy resolution of an X-ray source is described. This spectrometer is comprised of a thick silicon wafer having an embedded matrix or grid of aluminum completely through the wafer fabricated, for example, by thermal migration. The aluminum matrix defines the walls of a rectangular array of silicon X-ray detector cells or pixels. A thermally diffused aluminum electrode is also formed centrally through each of the silicon cells with biasing means being connected to the aluminum cell walls and causes lateral charge carrier depletion between the cell walls so that incident X-ray energy causes a photoelectric reaction within the silicon producing collectible charge carriers in the form of electrons which are collected and used for imaging

ENVIRONMENTAL POLICY INFLUENCES ON LIVESTOCK STOCKING AND LOCATION DECISIONS

This paper explores the relationship between state level environmental regulations and stocking and location decisions in the U.S livestock and poultry industry (beef, chicken, dairy and hogs). Rather than conduct this analysis on a species-by-species basis, we choose to focus upon the overall size of the livestock industry (expressed in animal units) and the size of industry found on large, medium and small operations by state (48) and over time (28 yrs). Results indicate that industry may drive policy rather than the converse. However, since we also find that existing policy rules have differential impacts on the industry by operation size, we conclude that structural change in the industry may be driven in part by size or legal structure discriminating regulations.Demand and Price Analysis, Livestock Production/Industries,

HEAO-1 spectra of X-ray emitting Seyfert 1 galaxies

The A-2 experiment on HEAO-1 determined spectral parameters for seven Seyfert 1 galaxies: NGC3783, NGC4151, NGC5548, NGC6814, MK509, MCG8-11-11, and ES0141-G55. The X-ray spectra above 5 keV can be well fit by power laws of energy index alpha between .3 and 1.0 and, with the exception of MK509, by a high temperature (kt 15 keV) thermal bremsstrahlung spectrum. The column densities, with the exception of NGC4151, are less than 5 x 10 to the 22nd power at/sq cm with only the low luminosity objects having measurable columns. Galaxy ES0141-G55 showed a strong soft X-ray excess in March 1978 similar to that seen in the BL lac object MK421. Variability on a six month time scale was exhibited by MCG8-11-11, NGC3783, and possibly NGC6814. Various correlations between optical and X-ray properties are discussed. Using the typical Seyfert 1 spectrum their contribution to the diffuse X-ray background above five keV is computed

On the monotonicity of scalar curvature in classical and quantum information geometry

We study the statistical monotonicity of the scalar curvature for the alpha-geometries on the simplex of probability vectors. From the results obtained and from numerical data we are led to some conjectures about quantum alpha-geometries and Wigner-Yanase-Dyson information. Finally we show that this last conjecture implies the truth of the Petz conjecture about the monotonicity of the scalar curvature of the Bogoliubov-Kubo-Mori monotone metric.Comment: 20 pages, 2 .eps figures; (v2) section 2 rewritten, typos correcte

Isolation of microsatellite loci in the Capricorn silvereye, Zosterops lateralis chlorocephalus (Aves : Zosteropidae)

The Capricorn silvereye (Zosterops lateralis chlorocephalus ) is ideally suited to investigating the genetic basis of body size evolution. We have isolated and characterized a set of microsatellite markers for this species. Seven out of 11 loci were polymorphic. The number of alleles detected ranged from two to five and observed heterozygosities between 0.12 and 0.67. One locus, ZL49, was found to be sex-linked. This moderate level of diversity is consistent with that expected in an isolated, island population